CCT facilitated learning new tasks in novel environments for several weeks, relative to unconditioned controls and control mice that avoided the same place during reduced distraction. We show that mice learned and remembered a conditioned place avoidance during CCT that required ignoring irrelevant locations of shock. Here we investigated whether CCT persistently alters hippocampal neural circuit function.
Could learning that uses cognitive control to judiciously use relevant information while ignoring distractions generally improve brain function, beyond forming explicit memories? According to a neuroplasticity hypothesis for how some cognitive behavioural therapies are effective, cognitive control training (CCT) changes neural circuit information processing 1, 2, 3.
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